Endocrine Abstracts

Cell therapy with Embryonic, Adult or iPSs Stem cells? As knowledge and scientific data start to increase the answer to that question seems still far away. Although all of them have in common their pluripotenciality and their infinite growth in vitro, the physiological regulation of stem cells in vivo is not really defined. Embryonic stem cells isolated from different steps from the initial embryonic development present in culture some different properties. New studies ...

Neuroendocrine tumours (NETs) are distinctive tumours which arise from cells which have neural and hormonal origins. Gastroenteropancreatic tumours (GEP) are the most common clinically encountered NETs. Imaging has a lead role in the evaluation of these tumours – detection, staging and follow-up. It is also known that PET–CT with 18F-FDG has a limited value in well-differentiated NETs. This study was performed to evaluate the clinical value of 18</sup...

Neoplasia and Endocrine Differentiation Research Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela. Santiago de Compostela, Spain. This has been an extraordinary year, where scientists have not been able to get close to the laboratory in many months. However, in the pituitary/hypothalamus we have outstanding contributions. Being at home does not mean stopping thinking, as highlighted by interesting reviews on th...

Introduction: Premenopausal women that suffer from osteoporosis are under-diagnosed and many anti-osteoporotic medications are neither licensed for young women, nor have they been established as safe or effective. Current guidelines on osteoporosis only address postmenopausal women, resulting in uncertainty and insufficient treatment for premenopausal women. To prevent bone fragility in young women, more knowledge and education about possible risk factors for osteoporosis in y...

Pheochromocytoma is a rare tumor made up of chromaffin cells from the adrenal medulla that secrete catecholamines. It can occur at any age, with a peak incidence between the fourth and fifth decade of life, and only 10% of cases occur in children. The majority of cases are sporadic and approximately 10% are malignant. The existence of familial syndrome, multiple or extra adrenal tumors is more common at younger ages. The clinic is very variable, and hypertension (HTA) is the m...

Introduction: MODYs are being identified more frequently but the rarity of some types still precludes in-dept knowledge of their natural course of disease. One of this rare forms is MODY 5, the result of a mutation on the hepatocyte nuclear factor 1 beta (HNF-1B) gene that associates with genitourinary and pancreatic malformations/dysfunction.Case report: A 24-year-old female was referred to the Endocrinology clinic due to hyperglycaemia identified on pr...

Introduction: Primary lymphoma of the thyroid (PTL) is a rare cause of malignancy, accounting for 5% of thyroid malignancies, with an annual estimated incidence of 2 per 1 million. Women are more commonly affected than men (2–8:1). Patients typically present in the sixth or seventh decade of life. Most thyroid lymphomas are non-Hodgkin’s lymphomas (NHLs) of B-cell origin. Patients with Hashimoto’s thyroiditis are at greater risk for developing PTL. Treatment and...

Introduction: Hypothalamic gonadotropin releasing hormone (GnRH) regulates mammalian reproductive system. It binds receptors (GnRHRs) expressed in gonadotrope cells of anterior pituitary, regulating the synthesis and secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). GnRHR is a G protein-coupled receptor (GPCR) coupled to Gαq/11 protein and, to a lesser extent, to Gαi/Gαs proteins, simultaneously activating Ca2+, β-cate...

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

A 57-year-old woman was referred in 2012 following an incidental finding of a pituitary macroadenoma. It measured 17×9 mm and was confined to the sella. There was no clinical or biochemical evidence of pituitary dysfunction. In 2017, she was found to have proximal myopathy, plethoric facies and purple abdominal striae. She was also on medication for hypertension and type 2 diabetes. There was no history of sleep apnoea, fractures or use of exogenous steroids. An MRI showe...